All Publications

Temperature Dependence of Turnover in a Sc(OTf)3-Catalyzed Intramolecular Schmidt Reaction
Charlie Fehl, Erin E. Hirt, Sze-Wan Li, and Jeffrey Aubé
Tetrahedron Letters 2015, 56 (23) , 3137-3140.
Potency Enhancement of the Kappa Opioid Receptor Antagonist Probe ML140 Through Sulfonamide Constraint Utilizing a Tetrahydroisoquinoline Motif
Kevin J. Frankowski, Stephen R. Slauson, Kimberly M. Lovell, Angela M. Phillips, John M. Streicher, Lei Zhou, David A. Whipple, Frank J. Schoenen, Thomas E. Prisinzano, Laura M. Bohn, and Jeffrey Aubé
Bioorganic and Medicinal Chemistry, 2015, 23, 3948–3956
An Efficient Computational Model To Predict Protonation at the Amide Nitrogen and Reactivity Along The C–N Rotational Pathway
Roman Szostak, Jeffrey Aubé, and Michal Szostak
Chem. Commun., 2015,51, 6395-6398
Identification and Validation of Novel Small Molecule Disruptors of HuR-mRNA Interaction
Xiaoqing Wu, Lan Lan. David Wilson, Rebecca Marquez, Wei-chung Tsao, Philip Gao, Anuradha Roy, Benjamin Turner, Peter McDonald, Jon Tunge, Steven Rogers, David A. Dixon, Jeffrey Aubé, and Liang Xu
ACS Chemical Biology, 2015, 10, 1476–1484
Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes
Stuart L. Schreiber, Joanne D. Kotz, Min Li, Jeffrey Aubé, Christopher P. Austin, John C. Reed, Hugh Rosen, E. Lucile White, Larry A. Sklar, Craig W. Lindsley, Benjamin R. Alexander, Joshua A. Bittker, Paul A. Clemons, Andrea de Souza, Michael A. Foley, Michelle Palmer, Alykhan F. Shamji, Mathias J. Wawer, Owen McManus, Meng Wu, Beiyan Zou, Haibo Yu, Jennifer E. Golden, Frank J. Schoenen, Anton Simeonov, Ajit Jadhav, Michael R. Jackson, Anthony B. Pinkerton, Thomas D.Y. Chung, Patrick R. Griffin, Benjamin F. Cravatt, Peter S. Hodder, William R. Roush, Edward Roberts, Dong-Hoon Chung, Colleen B. Jonsson, James W. Noah, William E. Severson, Subramaniam Ananthan, Bruce Edwards, Tudor I. Oprea, P. Jeffrey Conn, Corey R. Hopkins, Michael R. Wood, Shaun R. Stauffer, Kyle A. Emmitte, and NIH Molecular Libraries Project Team
Cell, 2015, 161, 1252–1265
Natural Product (–)-Gossypol Inhibits Colon Cancer Cell Growth by Targeting RNA-Binding Protein Musashi-1
Lan Lan, Carl Appelman, Amber R. Smita, Jia Yu, Sarah Larsen, Rebecca T. Marquez, Hao Liu, 1, Xiaoqing Wu, Philip Gao, Anuradha Roy, Asokan Anbanandam, Ragul Gowthaman, John Karanicolas, Roberto N. De Guzman, Steven Rogers, Jeffrey Aubé, Min Ji, Robert S. Cohen, Kristi L. Neufeld, and Liang Xu
Molecular Oncology, 2015, 9, 1406–1420
Structure–Activity Relationship Studies of Functionally Selective Kappa Opioid Receptor (KOR) Agonists that Modulate ERK 1/2 Phosphorylation While Preserving G Protein Over βArrestin2 Signaling Bias
Kimberly M Lovell, Kevin J. Frankowski, Edward L. Stahl, Stephen R. Slauson, Euna Yoo, Thomas E. Prisinzano, Jeffrey Aubé, and Laura M. Bohn
10.1021/acs.joc.5b00804
Domino Acylation/Diels–Alder Synthesis of N-Alkyl-octahydroisoquinolin-1-one-8-carboxylic Acids Under Low-Solvent Conditions
Domino Acylation/Diels–Alder Synthesis of N-Alkyl-octahydroisoquinolin-1-one-8-carboxylic Acids Under Low-Solvent Conditions
Journal of Organic Chemistry, 2015, 80, 5260–5271
DARC: Mapping Surface Topography by Ray-Casting for Effective Virtual Screening at Protein Interaction Sites
Ragul Gowthaman, Sven A. Miller, Steven Rogers, Jittasak Khowsathit, Lan Lan, Nan Bai, David K. Johnson, Chunjing Liu, Liang Xu, Asokan Anbanandam, Jeffrey Aubé, Anuradha Roy, and John Karanicolas
Journal of Medicinal Chemistry, 2015, 59, 4152-4170
Practical Electrochemical Anodic Oxidation of Polycyclic Lactams for Late Stage Functionalization
Kevin J. Frankowski, Ruzhang Liu, Gregory L. Milligan, Kevin D. Moeller and Jeffrey Aubé
Angewandte Chemie, International Edition, 2015, 54, 10555–10558
Characterization of Kappa Opioid Receptor Mediated, Dynorphin-Stimulated [35S]GTPS Binding in Mouse Striatum for the Evaluation of Selective KOR Ligands in an Endogenous Setting
Characterization of Kappa Opioid Receptor Mediated, Dynorphin-Stimulated [35S]GTPS Binding in Mouse Striatum for the Evaluation of Selective KOR Ligands in an Endogenous Setting
Neuropharmacology, 2015, 99, 131–141
Determination of Structures and Energetics of Small- and Medium-Sized One-Carbon Bridged Twisted Amides using ab Initio Molecular Orbital Methods: Implications for Amidic Resonance along the C–N Rotational Pathway
Roman Szostak, Jeffrey Aubé, and Michal Szostak
Journal of Organic Chemistry, 2015, 80, 7905–7927
A Pan-GTPase Inhibitor as a Molecular Probe
Lin Hong, Yuna Guo, Soumik BasuRay, Denise Simpson, Chad E. Schroeder,Peter Simons,Anna Waller, Matthew Garcia, Mark Carter, Oleg Ursu, Kristine Gouveia, Jennifer E. Golden, Jeffrey Aubé, Angela Wandinger-Ness, and Larry A. Sklar
PLOS One, 2015, 10, e0134317–.
Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore
Sudeshna Roy, Justina Šileikytė, Marco Schiavone, Benjamin Neuenswander, Francesco Argenton, Jeffrey Aubé, Michael P. Hedrick, Thomas D. Y. Chung, Michael A. Forte, Paolo Bernardi, and Frank J. Schoenen
ChemMedChem, 2015, 10, 1655–1671
Investigation of the Role of βarrestin2 in Kappa Opioid Receptor Modulation in a Mouse Model of Pruritus
Jenny Morgenweck, Kevin J. Frankowski, Thomas E. Prisinzano, Jeffrey Aubé, Laura M. Bohn
10.1016/j.neuropharm.2015.08.027
High-throughput Screening, Discovery and Optimization to Develop a Benzofuran Class of Hepatitis C Virus Inhibitors
Shanshan He, Prashi Jain, Billy Lin, Marc Ferrer, Zongyi Hu, Noel Southall, Xin Hu, Wei Zheng, Benjamin Neuenswander, Chul-Hee Cho, Yu Chen, Shilpa A. Worlikar, Jeffrey Aubé, Richard C. Larock, Frank J. Schoenen, Juan J. Marugan, T. Jake Liang, and Kevin J. Frankowski
ACS Combinatorial Science, 2015, 17, 641-652
Intramolecular Friedel–Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoroisopropanol
Hashim Motiwala, Rakesh Vekariya, and Jeffrey Aubé
Organic Letters, 2015, 17, 5484–5487
N-Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore
Sudeshna Roy, Justina Šileikytė, Benjamin Neuenswander, Michael P. Hedrick, Thomas D. Y. Chung, Jeffrey Aubé, Frank J. Schoenen, Michael A. Forte, and Paolo Bernardi
ChemMedChem, 2015, 11, 283–288
Improved Schmidt Conversion of Aldehydes to Nitriles Using Azidotrimethylsilane in 1,1,1,3,3,3-Hexafluoro-2-propanol
Hashim F. Motiwala, Qin Yin, and Jeffrey Aubé
Molecules, 2016, 21, 45
Remodeling and Enhancing Schmidt Reaction Pathways in Hexafluoroisopropanol
Hashim F. Motiwala, Manwika Charaschanya, Victor W. Day, and Jeffrey Aubé
Journal of Organic Chemistry, 2016, 81, 1593–1609
Efficient Access To sp3-Rich Tricyclic Amine Scaffolds Through Diels-Alder Reactions of Azide-Containing Silyloxydienes
Michael C. McLeod and Jeffrey Aubé
Tetrahedron, 2016, 72, 3766–3774
One-Pot, Regiospecific Assembly of (E)-Benzamidines From δ- and γ-Amino Acids Via an Intramolecular Aminoquinazolinone Rearrangement
Chad E. Schroeder, Sarah A. Neuenswander, Tuanli Yao, Jeffrey Aubé, and Jennifer E. Golden
Organic and Biomolecular Chemistry, 2016, 14, 3950–3955

Synthesis of Cyclic 1,3-Diols as Scaffolds for Spatially Directed Libraries
Gurpreet Singh and Jeffrey Aubé
Organic and Biomolecular Chemistry, 2016, 14, 4299–4303
Novel Cephalosporins Selectively Active on Non-replicating Mycobacterium tuberculosis
Ben Gold, Robert Smith, Quyen Nguyen, Julia Roberts, Yan Ling, Landys Lopez Quezeda, Selin Somersan-Karakaya, Thulasi Warrier, David Little, Maneesh Pingle, David Zhang, Elaine Ballinger, Matthew Zimmerman, Veronique Dartois, Paul Ronald Hanson, Lester A. Mitscher, Patrick Porubsky, Steven Rogers, Frank J. Schoenen, Carl F. Nathan, and Jeffrey Aubé
Journal of Medicinal Chemistry, 2016, 59, 6027–6044
Synthesis of Kappa Opioid Antagonists Based On Pyrrolo[1,2-alpha]quinoxalinones Using an N-Arylation/Condensation/Oxidation Reaction Sequence
Sarah M. Scarry, Kimberly M. Lovell, Kevin J. Frankowski, Laura M. Bohn, and Jeffrey Aubé
Journal of Organic Chemistry, 2016, 81, 10538–10550
Hexafluoro-2-propanol-Promoted Intermolecular Friedel-Crafts Acylation Reaction
Rakesh Vekariya and Jeffrey Aubé
Organic Letters, 2016, 18, 3534–3537
Activation of HuR Downstream of p38 MAPK Promotes Cardiomyocyte Hypertrophy
Samuel Slone, Sarah R. Anthony, Xiaoqing Wu, Joshua B. Benoit, Jeffrey Aube, Liang Xu, Michael Tranter
Cellular Signaling, 2016, 28, 1735–1741
Decahydrobenzoquinolin-5-one Sigma Receptor Ligands: Divergent Development of Both Sigma 1 and Sigma 2 Receptor Selective Examples
Michael C. McLeod, Jeffrey Aubé, and Kevin J. Frankowski
Bioorganic and Medicinal Chemistry Letters, 2016, 26, 5689–5694
Biased Agonists of the Kappa Opioid Receptor Suppress Pain and Itch Without Causing Sedation and Dysphoria
Tarsis F. Brust, Jenny Morgenweck, Susy A. Kim, Jamie H. Rose, Jason Locke, Cullen L. Schmid, Lei Zhou, Edward L. Stahl, Michael D. Cameron, Sarah M. Scarry, Jeffrey Aubé, Sara L. Jones, Thomas J. Martin, and Laura M. Bohn
Science Signaling, 2016, 9, ra117
Structural and Functional Evaluation of Clinically-Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1 (CYP17A1)
Elyse M. Petrunak, Steven A. Rogers, Jeffrey Aubé, and Emily E. Scott
Drug Metabolism and Disposition, 2017, 45, 635–645
Identification, Biological Evaluation and Structure-Activity Relationship of Novel Small Molecule Beclin 1 Mimetics Modulating Autophagy
Jia Yu, Lan Lan, Anuradha Roy, Steven A. Rogers, Xiaoqing Wu, Philip Gao, John Karanicolas, Jeffrey Aubé, Baiwang Sun, and Liang Xu
Oncotargets, 2017, 8, 51355–51369
HuR-targeted Small Molecule Inhibitor Exhibits Cytotoxicity Towards Human Lung Cancer Cells
Ranganayaki Muralidharan, Meghna Mehta, Rebaz Ahmed, Sudeshna Roy, Liang Xu, Jeffrey Aubé, Allshine Chen, Yan Daniel Zhao, Terence Herman, Rajagopal Ramesh, Anupama Munshi
Scientific Reports, 2017, 7, 9674
Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle
Shanshan He, Kelin Li, Billy Lin, Zongyi Hu, Jingbo Xiao, Xin Hu, Amy Q. Wang, Xin Xu, Marc Ferrer, Noel Southall, Wei Zheng, Jeffrey Aubé, Frank J. Schoenen, Juan J. Marugan, T. Jake Liang, and Kevin J. Frankowski
Journal of Medicinal Chemistry, 2017, 60, 6364–6383
Seeking (and Finding) Biased Ligands of the Kappa Opioid Receptor
Laura M. Bohn and Jeffrey Aubé
ACS Medicinal Chemistry Letters, 2017, 8, 694–700
Optimization and Evaluation of Antiparasitic Benzamidobenzoic Acids as Inhibitors of Kinetoplastid Hexokinase 1
Daniel P. Flaherty, Michael T. Harris, Chad E. Schroeder, Haaris Khan, Elizabeth W. Kahney, Amber L. Hackler, Stephen L. Patrick, Warren S. Weiner, Jeffrey Aubé, Elizabeth R. Sharlow, James C. Morris, and Jennifer E. Golden
ChemMedChem, 2017, 12, 1994–2005
Hexafluoroisopropanol and Acetyl Chloride Promoted Catalytic Hydroarylation with Phenols
Sudeshna Roy, Hashim F. Motiwala, Karl M. Koshlap, and Jeffrey Aubé
European Journal of Organic Chemistry, 2018, 306–315
Synthesis, Stabilization, and Characterization of the MR1 Ligand Precursor 5-Amino-6-D-ribitylaminouracil (5-A-RU)
Kelin Li, Charles K. Vorkas, Ashutosh Chaudhry, Donielle L. Bell, Richard A. Willis, Alexander Rudensky, John D. Altman, Michael S. Glickman, and Jeffrey Aubé
PLOS One, 2018, 13, e0191837
Reagent-Controlled Regiodivergent Ring Expansions of Steroids
Manwika Charaschanya and Jeffrey Aubé
Nature Communications, 2018, 9, 934
Structure–Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D2 Dopamine Receptor
Lani S. Chun, Rakesh H. Vekariya, R. Benjamin Free, Yun Li, Da-Ting Lin, Ping Su, Fang Liu, Yoon Namkung, Stéphane Alain Laporte, Amy E. Moritz, Jeffrey Aubé, Kevin J Frankowski, David R Sibley
Frontiers in Synaptic Neuroscience, 2018, 10, Article 2
Metarrestin, a Potent Perinucleolar Compartment Inhibitor, Effectively Suppresses Metastasis
Kevin J. Frankowski, Chen Wang, Samarjit Patnaik, Frank J. Schoenen, Noel Southall, Dandan Li, Yaroslav Teper, Wei Sun, Irawati Kandela, Deqing Hu, Christopher Dextras, Zachary Knotts, Yansong Bian, John Norton, Steve Titus, Marzena A. Lewandowska, Yiping Wen, Katherine I. Farley, Lesley Mathews Griner, Jamey Sultan, Zhaojing Meng, Ming Zhou, Tomas Vilimas, Astin S. Powers, Serguei Kozlov, Kunio Nagashima, Humair S. Quadri, Min Fang, Charles Long, Ojus Khanolkar, Warren Chen, Jinsol Kang, Helen Huang, Eric Chow, Esthermanya Goldberg, Coral Feldman, Romi Xi, Hye Rim Kim, Gary Sahagian, Susan J. Baserga, Andrew Mazar, Marc Ferrer, Wei Zheng, Ali Shilatifard, Jeffrey Aubé, Udo Rudloff, Juan Jose Marugan, and Sui Huang
Science Translational Medicine, 2018, 10, eaap8307
Structure-based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2
Charlie Fehl, Caleb D. Vogt, Rahul Yadav, Kelin Li, Emily E. Scott, and Jeffrey Aubé
Journal of Medicinal Chemistry, 2018, 61, 4946–4960
Application of the DP4 Probability Method to Flexible Cyclic Peptides with Multiple Independent Stereocenters: The True Structure of Cyclocinamide A
Jason K. Cooper, Kelin Li, Jeffrey Aubé, David A. Coppage, and Joseph P. Konopelski
Organic Letters, 2018, 20, 4314–4317
G Protein Signaling Biased Agonism at the Kappa Opioid Receptor is Maintained in Striatal Neurons
Jo-Hao Ho, Edward L. Stahl, Cullen L. Schmid, Jeffrey Aubé, and Laura M. Bohn
Science Signaling, 2018, 11, eaar4309
Identification of Positive Allosteric Modulators of the D1 Dopamine Receptor that Act at Diverse Binding Sites
Kathryn D. Luderman, Jennie L. Conroy, R. Benjamin Free, Noel Southall, Marc Ferrer, Marta Sanchez-Soto, Amy E. Moritz, Blair K.A. Willette, Tim J. Fyfe, Prashi Jain, Steve Titus, Lisa A. Hazelwood, Jeffrey Aubé, J. Robert Lane, Kevin J. Frankowski, and David R. Sibley
Molecular Pharmacology, 2018, 94
Musocal-associated Invariant and γδ T Cell Subtypes Respond to Early Mycobacterium tuberculosis Infection
Charles Vorkas, Matthew F. Wipperman, Kelin Li, James Bean, Shakti K. Bhattarai, Matthew Adamow, Phillip Wong, Jeffrey Aubé, Marc Antoine Jean Juste, Vanni Bucci, Daniel W. Fitzgerald, and Michael S. Glickman
JCI Insight, 2018, 3, e121899
An Interrupted Schmidt Reaction: C–C Bond Formation Arising from Nitrilium Ion Capture
Manwika Charaschanya, Kelin Li, Hashim Motiwala, and Jeffrey Aubé
Organic Letters, 2018, 20, 6354–6358
Hexafluoro-2-propanol-promoted Intramolecular Friedel-Crafts Acylation
Rakesh H. Vekariya, Matthew C. Horton, and Jeffrey Aubé
Organic Syntheses, 2018, 95, 486-499
Natural Product Derivative Gossypolone Inhibits Musashi family of RNA-binding Proteins
Lan Lan, Hao Liu, Amber R Smith, Carl Appelman, Jia Yu, Sarah Larsen, Rebecca T Marquez, Xiaoqing Wu, Frank Y Liu, Philip Gao, Ragul Gowthaman, John Karanicolas, Roberto N De Guzman, Steven Rogers, Jeffrey Aubé, Kristi L Neufeld, and Liang Xu
BMC Cancer, 2018, 18, 809
The Ex Vivo Treatment of Donor T cells with Cosalane, an HIV Therapeutic and Small Molecule Antagonist of CC-Chemokine Receptor 7, Separates Acute Graft-versus-Host Disease from Graft-versus-Leukemia Responses in Murine Hematopoietic Stem Cell Transplant Models
Kenneth A Fowler, Kelin Li, Christopher B Whitehurst, Danny W Bruce, Nathaniel J Moorman, Jeffrey Aubé, and James M Coghill
Biology of Blood and marrow Transplantation, 2019, 25, 1062-1074
Combinatorial Chemistry and Its Associated Technologies
Nicholas J. Klus, Lester A. Mitscher, and Jeffrey Aubé
Wiley. In press

Human Antigen R as a Therapeutic Target in Pathological Cardiac Hypertrophy
Lisa C Green, Sarah R Anthony, Samuel Slone, Lindsey Lanzillotta, Michelle L Nieman, Xiaoqing Wu, Nathan Robbins, Shannon M Jones, Sudeshna Roy, A Phillip Owens III, Jeffrey Aube, Liang Xu, John N Lorenz, Burns C Blaxall, Jack Rubinstein, Joshua B Benoit, and Michael Tranter
JCI Insight, 2019, 4, e121541
Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition
Elaine Ballinger, John Mosior, Travis Hartman, Kristin Burns-Huang, Ben Gold, Roxanne Morris, Laurent Goullieux, Isabelle Blanc, Julien Vaubourgeix, Sophie Lagrange, Laurent Fraisse‖, Stéphanie Sans, Cedric Couturier, Eric Bacqué, Kyu Rhee, Sarah M. Scarry, Jeffrey Aubé, Guangbin Yang, Ouathek Ouerfelli, Dirk Schnappinger, Thomas R. Ioerger, Curtis A. Engelhart, Jennifer A. McConnell, Kathrine McAulay, Allison Fay, Christine Roubert, James Sacchettini, and Carl Nathan
Science, 2019, 363, 498 and eeau8959
Synthesis of the Non-ribosomal Peptide Phevalin and Analogs
Remya Ramesh, Michael T. Bovino, Yibin Zeng, and Jeffrey Aubé, Journal of Organic Chemistry
Journal of Organic Chemistry, 2019, 84, 3647–3651
Effect of C-2 Substitution on the Stability of Non-traditional Cephalosporins in Mouse Plasma
Matthew Zimmerman, Stacey L. McDonald, Hsin-Pin Ho-Liang, Patrick Porubsky, Quyen Nguyen, Cameron W. Pharr, Andrew J. Perkowski, Robert Smith, Frank J. Schoenen, Ben S. Gold, David Zhang, Carl F. Nathan, Véronique Dartois, and Jeffrey Aubé
Journal of Antibiotics, 2019, 72, 469–475
Synthesis and Antibacterial Evaluation of Cephalosporin Isosteres
Drew J. Cesta, Selin Somersan Karakaya, Kohta Saito, Prisca E. Javidnia, Julia Roberts, Yan Ling, Ben S. Gold, Landys Lopez Quezada, David Zhang, Tigran M. Abramyan, Dmitri B. Kireev, Jeffrey Aubé, and Sarah M. Scarry
Asian Journal of Organic Chemistry, 2019, 8, 1053–1057
The HuR CMLD-2 Inhibitor Exhibits Antitumor Effects via MAD2 Downregulation in Thyroid Cancer Cells
Lorenzo Allegri, Federica Baldan, Sudeshna Roy, Jeffrey Aubé, Diego Russo, Sebastiano Filetti, and Giuseppe Damante
Scientific Reports, 2019, 9, article number 7374
Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis
Landys Lopez Quezada, Kelin Li, Stacey L. McDonald, Quyen Nguyen, Andrew J. Perkowski, Cameron W. Pharr, Ben Gold, Julia Roberts, Kathrine McAulay, Kohta Saito, Selin Somersan Karakaya, Prisca Elis Javidnia, Esther Porras de Francisco, Manuel Marin Amieva, Sara Palomo Diaz, Alfonso Mendoza Losana, Matthew Zimmerman, Hsin-Pin Ho Liang, Jun Zhang, Veronique Dartois,Stéphanie Sans, Sophie Lagrange, Laurent Goullieux, Christine Roubert, Carl Nathan, and Jeffrey Aubé
ACS Infectious Diseases, 2019, ASAP.
Target Deconvolution of a Multikinase Inhibitor with Anti-Metastatic Properties Identifies TAOK as a Key Contributor to a Cancer Stem Cell-like Phenotype
Yansong Bia, Yaroslav Teper, Lesley A. Mathews Griner, Taylor J. Aiken,, Vivek Shukla, Rajarshi Guha, Paul Shinn, Hong-Wu Xin, Holger Pflicke, Astin Powers, Dandan Li, Jian-kang Jiang, Paresma Patel, Steven A. Rogers, Jeffrey Aubé, Marc Ferrer, Craig J. Thomas, and Udo Rudloff
Molecular Cancer Therapeutics, 2019, accepted

Preclinical Testing of Nalfurafine as a Potential Adjuvant to Reduce the Addictive Potential of the Mu Opioid Receptor-targeting Analgesic Morphine
Shane W. Kaski, Joshua D. Gross, Kristen R. Trexler, Kim Wix, Aubrie A. Harland, Thomas Edward Prisinzano, Jeffrey Aubé, Steven G. Kinsey, Terry Kenakin, David Siderovski, and Vincent Setola
Journal of Pharmacology and Experimental Therapeutics, 2019, online
Revisiting the β-Lactams for Tuberculosis Therapy: A Compound–compound Synthetic Lethality Approach
Shiqi Xiao, Haidan Guo, Warren Weiner, Clinton Maddox, Chunhong Mao, Hendra Gunosewoyo, Shaaretha Pelly, E. Lucile White, Lynn Rasmussen, Frank Schoenen, Jeffrey Aubé, William Bishai, and Shichun Lun
Antimicrobial Agents and Chemotherapy, 2019, online.
Bactericidal Disruption of Magnesium Metallostasis in Mycobacterium tuberculosis Is Counteracted by Mutations in the Metal Ion Transporter CorA
Landys Lopez Quezada, Sandra Silve, Mark Kelinske, Amir Liba, Constantino Diaz Gonzalez, Martin Kotev, Laurent Goullieux, Stephanie Sans, Christine Roubert, Sophie Lagrange, Eric Bacqué, Cedric Couturier, Alain Pellet, Isabelle Blanc, Marlène Ferron, Fabrice Debu, Kelin Li, Jeffrey Aubé, Julia Roberts, David Little, Yan Ling, Jun Zhang, Ben Gold, and Carl Nathan
mBio, 2019, 10, e01405-19
Tumor Suppressor TET2 Promotes Cancer Immunity and Immunotherapy Efficacy
Yan-ping Xu, Lei Lv, Ying Liu, Matthew D. Smith, Wen-Cai Li, Xian-ming Tan, Meng Cheng, Zhijun Li, Michael Bovino, Jeffrey Aubé, and Yue Xiong
Journal of Clinical Investigation, 2019, in-press review
Can They Imagine the Future? A Qualitative Study Exploring the Skills Employers Seek in Pharmaceutical Sciences Doctoral Graduates
Jacqueline E. McLaughlin, Lana M. Minshew, Daniel Gonzalez, Kelsey Lamb, Nicholas J. Klus, Jeffrey Aubé, Wendy Cox, Kim L. R. Brouwer
PLOS One, 2019, online
MAIT Cells are Imprinted by the Microbiota in Early Life and Promote Tissue Repair
Michael G. Constantinides, Verena M. Link, Samira Tamoutounour, Andrea C. Wong, P. Juliana Perez-Chaparro, Seong Ji Han, Y. Erin Chen, Kelin Li, Sepideh Farhat, Antonin Weckel, Siddharth R. Krishnamurthy, Ivan Vujkovic-Cvijin, Jonathan L. Linehan, Nicolas Bouladoux, E. Dean Merrill, Sobhan Roy, Daniel J. Cua, Erin J. Adams, Avinash Bhandoola, Tiffany C. Scharschmidt, Jeffrey Aubé, Michael A. Fischbach, and Yasmine Belkaid
Science, 2019, 366, eaax6624
HuR reduces radiation-induced DNA damage by enhancing expression of ARID1A
Daniel Andrade, Meghna Mehta, James Griffith, Sangphil Oh, Joshua Corbin, Anish Babu, Supriyo De, Allshine Chen, Sanam Husain, Yan Zhao, Sudeshna Roy, Liang Xu, Jeffrey Aubé, Ralf Janknecht, Myriam Grospe, Terence Herman, Rajagopal Ramesh, And Anupama Munshi
Corbin, Anish Babu, Supriyo De, Allshine Chen, Sanam Husain, Yan Zhao,
Sudeshna Roy, Liang Xu, Jeffrey Aube, Ralf Janknecht, Myriam Gorospe, Terence
Herman, Rajagopal Ramesh, and Anupama Munshi
J. Org. Chem. 2019, 84, 6, 3647-3651

Publications