Natural Product Total Synthesis

Since the inception of the Aubé lab, natural product synthesis has been an ongoing facet of our research. For us, part of the satisfaction of natural product synthesis lies with the development of new and powerful chemical tools to overcome unique synthetic challenges; the other lies in discovering the biological activities of the target molecules once we have accomplished their synthesis. Some highlighted examples of natural products produced in the lab are below and their respective syntheses are revealed by clicking on their structure.
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-adrenergic antagonist

- quantified late-stage Fischer indole construction reported by Stork

- favorite step: an internal redox ketalization